This is not a complete list of side effects and others may occur. More about ranitidine and hyperprolactinaemia [letter]. To learn more, see the Side effects of Nexplanon insertion and removal section below. It can also lead to irregular or missed periods. You may become pregnant if the implant comes out by itself. These may include changes in bleeding frequency, intensity, duration, or amenorrhea. If your doctor confirms youve had a serious allergic reaction to Nexplanon, they may have you switch to a different treatment. In some cases, serious belly pain or cramping can be a sign of an ectopic pregnancy. Drug-related causes . Nexplanon may cause nausea, but this wasnt a common side effect reported in studies of the drug. A single, thin rod measuring 1.6 inches long, about the size of a matchstick, Nexplanon is discreet. The 6 Best Services for Birth Control Online for 2023, itchiness at the site where Nexplanon is inserted, pain or itching at the site where Nexplanon is inserted, bleeding or bruising where Nexplanon is inserted, thickening of your skin where the implant is inserted, more or less frequent bleeding during your period, changes in the heaviness of your bleeding, losing interest in things you used to enjoy, swelling under your skin, usually in your eyelids, lips, hands, or feet, swelling of your mouth, tongue, or throat, which can make it hard to breathe, an over-the-counter antihistamine that you swallow, such as, a product you apply to your skin, such as hydrocortisone cream, how soon you had the side effect after getting the implant, any other information you feel is important. Diet can also play a role as certain vitamin deficiencies and under-eating, as seen with anorexia nervosa, can cause high prolactin. . A few women who use birth control that contains hormones may get: If you feel you have a broken or bent implant, please contact your doctor. Some clinical conditions resulting in high prolactin levels in non-pregnant females are; Idiopathic hyper-prolactinemia - Meaning no known cause (about 40% cases) Tumors of the . Circulating hormone levels in menopausal women receiving different hormone replacement therapy regimens: a comparison. But there havent been side effects reported in children who were exposed to etonogestrel through breast milk. It is possible to die from a problem caused by a blood clot, such as a heart attack or stroke. Critical to an understanding of the ways in which medications affect prolactin (PRL) secretion is an explanation of the neuroendocrine regulation of PRL secretion. Implants have been reported to be found in a blood vessel, including a blood vessel in the lung. here are some other possible risks with NEXPLANON. NEXPLANON does not protect against HIV or other STDs. If you have diabetes or prediabetes, your body may already have trouble regulating your blood sugar. Lack of adverse interactions between concomitantly administered selegiline and citalopram. If you experience nausea with Nexplanon, talk with your doctor. Spotting is a common side effect of Nexplanon, but you should still tell your doctor if you experience it. Liver problems. If youve had breast cancer or other hormone-related cancer before, Nexplanon may raise your risk of it coming back. Hyperprolactinemia can result from three major causes including stress-response, pharmacology, and pathologic etiologies. An exploratory haloperidol-controlled dose-finding study of ziprasidone in hospitalized patients with schizophrenia or schizoaffective disorder. Most Nexplanon drug interactions, however, are minor. These are more common in women as compared to men. The effects of paroxetine and tianeptine on peripheral biochemical markers in major depression. But alcohol may make certain side effects of Nexplanon worse. In studies, people with Nexplanon gained an average of 2.8 pounds (lb) in 1 year and 3.7 lb in 2 years. But like other kinds of birth control, Nexplanon is not 100% effective. Nexplanon (etonogestrel) will be implanted just below the skin, so you can feel it at all times. Hormonal birth control such as Nexplanon can cause your liver problems to get worse. Prolactin levels and adverse events in patients treated with risperidone. Hormonal and metabolic effects of transdermal estradiol/progestagen administration in postmenopausal women. Hyperprolactinemia caused by medications is commonly symptomatic, causing galactorrhea, menstrual disturbance, and impotence. The drug comes as an implant thats inserted under the skin of your arm by a healthcare professional. Effect of acute and chronic neuroleptic therapy on serum prolactin levels in men and women of different age groups. Dynamics of prolactin secretion in patients with hypopituitarism and pituitary macroadenomas. Unusual genital bleeding. Breast pain was a common side effect that people with Nexplanon reported in studies. 1 Dr Molitch is currently receiving research support from Pfizer, Inc, Novartis Pharmaceuticals Corp, Sanofi-Aventis Pharmaceuticals, and Amgen Inc and is serving as a consultant to Abbott Laboratories., Address reprint requests and correspondence to Mark E. Molitch, MD, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, 303 E Chicago Ave (Tarry 15-731), Chicago, IL 60611, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill. Mildly elevated prolactin - less than 100 ng/ml - usually occurs in conditions which are not serious. High levels of prolactin in the blood can cause various symptoms, such as headaches. We avoid using tertiary references. Prolactin levels during long-term risperidone treatment in children and adolescents. * Frequency of increase to abnormal prolactin levels with chronic use: high: >50%; moderate: 25 to 50%; low: <25%; none or low . The best birth control options for endometriosis include birth control pills, the vaginal ring, and the patch. What to Know About Birth Control Options That Stop Your Period, 6 Most Important Things to Consider When Choosing Your Birth Control, 8 of the Best Birth Control Options to Ease Heavy Periods, Birth Control for Endometriosis: How It Works, Types, and Alternatives, How Government and Religious Organizations Can Affect Your Birth Control Options, Debra Sullivan, Ph.D., MSN, R.N., CNE, COI. Relation of serum molindone levels to serum prolactin levels and antipsychotic response. You may become pregnant if the implant comes out by itself. If you have one of these conditions, talk with your doctor before getting Nexplanon. -Endorphin-induced decrease in hypothalamic dopamine turnover. You may experience side effects after your doctor inserts or removes the Nexplanon implant. Your arm will be sterilized first, then a local anesthetic will be applied. Allergic reaction. Serum-prolactin in patients receiving chronic oral cimetidine [letter]. When prolactin levels shift, you might not notice any obvious signs or symptoms at first. Some people also experience acne, weight gain, and breast pain. High levels of estrogens present during pregnancy are known to cause lactotroph hyperplasia and hyperprolactinemia. Nexplanon can prevent pregnancy for up to five years, and . Common side effects of Nexplanon include changes in menstrual bleeding, headache, and vaginal pain. Hyperprolactinemia-galactorrhea induced by verapamil [letter]. Effects of desipramine and fluvoxamine treatment on the prolactin response to tryptophan: serotonergic function and the mechanism of antidepressant action. Our website services, content, and products are for informational purposes only. Growth and sexual maturation during long-term treatment with risperidone. Nexplanon (etonogestrel) can cause some serious health issues. The precise roles of these peptides and other PRL-releasing factors such as TRH are unclear. However, in men it can cause erectile dysfunction . Feeling nervous and excitable. Nexplanon is a hormonal birth control, but its not known whether it can cause gallbladder disease. Implants have been reported to be found in a blood vessel, including a blood vessel in the lung. Some women have high prolactin levels without any symptoms. Approximately 36% of participants had higher prolactin levels during the luteal phase. However, women who are nursing can use Nexplanon without presenting a health risk to the infant. Hyperprolactinemia (High Prolactin Levels) | Causes, Signs & Symptoms, Diagnosis, TreatmentHyperprolactinemia is a medical condition that involves high level. How Effective Is Each Birth Control Method? Call your healthcare provider right away if you think you are pregnant or have unexplained lower stomach (abdominal) pain. The birth control implant is a tiny, thin rod about the size of a matchstick. The average weight gain was nearly three pounds one year after implant and close to four pounds two years after implant. Of the currently used antihypertensive medications, verapamil is the only one that causes hyperprolactinemia. Although these side effects werent reported in studies, theyve been reported by people who got Nexplanon after it was approved for use. Other breast-related side effects that people with Nexplanon reported after it was approved include: If you have breast pain with Nexplanon, talk with your doctor. Plasma prolactin concentrations in normal subjects and depressive patients following oral clomipramine. Plasma prolactin in schizophrenia subjects treated with Seroquel. In humans, morphine and morphine analogues increase PRL release both short-term. Intrauterine devices (IUDs) are commonly used as contraceptive devices. For example, both Nexplanon and alcohol can cause headache, nausea, and liver problems. For more information about side effects you could have when Nexplanon is inserted or removed, see the Side effects of Nexplanon insertion and removal section above. Consider taking notes on any side effects youre having with Nexplanon. A change or stop in ovulation, due to changes in the production of hormones estrogen and progesterone. Bruising or itchiness can occur because Nexplanon is inserted under your skin. It can also develop, to a lesser extent, with some . To ascertain the frequency of this clinical problem and to develop treatment guidelines, the medical literature was searched by using PubMed and the reference lists of other articles dealing with hyperprolactinemia due to specific types of medications. Medication use is a common cause of hyperprolactinemia, and it is important to differentiate this cause from pathologic causes, such as prolactinomas. Symptoms from the high prolactin levels include discharge of milk from the breast (galactorrhoea) and breast tenderness. If you have liver problems, including liver tumors or liver disease, talk with your doctor before getting Nexplanon. These are not all of the side effects that may occur. Cocaine effects on pulsatile secretion of anterior pituitary, gonadal, and adrenal hormones. There are some serious side effects with Nexplanon, but they're very rare. (1) mildly increased prolactin levels (400-600mu/L) may be physiological and asymptomatic but higher levels are usually pathological should be repeated to confirm hyperprolactinaemia; very elevated levels (above 5,000mu/L) usually imply a prolactin-secreting pituitary tumour If the side effects seem life threatening or you think youre having a medical emergency, immediately call 911 or your local emergency number. Plasma-prolactin and cimetidine [letter]. You should not use NEXPLANON if you are pregnant or think you may be pregnant; have or have had blood clots; have liver disease or a liver tumor; have unexplained vaginal bleeding; have breast cancer or any other cancer that is sensitive to progestin (a female hormone), now or in the past; or are allergic to anything in NEXPLANON. High prolactin levels can occur due to a variety of reasons. Hyperprolactinemia is a recognized cause of secondary osteoporosis, and treatment with dopamine . If you become pregnant while using NEXPLANON, you have a slightly higher chance that the pregnancy will be ectopic (occurring outside the womb) than do women who do not use birth control. flu-like symptoms, sore throat. The signs and symptoms differ slightly between men, women and children. In contrast, if a patient has highly symptomatic hyperprolactinemia that, along with amenorrhea, causes decreased libido, bothersome galactorrhea, impotence, or osteoporosis, then a more active treatment strategy is necessary. In 1 series of 7 patients with hyperprolactinemia and galactorrhea from various antipsychotic medications who were treated with bromocriptine, 2 achieved normal PRL levels, 4 experienced considerable decreases in PRL levels, and galactorrhea improved in all. High blood pressure. There are many antihypertensive agents; therefore, switching a patient from verapamil to an alternative generally should not be a problem. Depression. You are encouraged to report negative side effects of prescription drugs to the FDA. Treatment is needed only if the hyperprolactinemia is symptomatic. If this cannot be done, MRI or computed tomography will exclude a structural lesion. Yes, Nexplanon can cause cramps or belly pain. Yes, Nexplanon may cause long-term changes in your period bleeding. Prolactin serum levels in postmenopausal women receiving long-term hormone replacement therapy. .css-15vdq8k{font-weight:var(--chakra-fontWeights-bold);font-family:var(--chakra-fonts-default);font-size:14px;}@media screen and (min-width: 40em){.css-15vdq8k{font-size:21px;}}Immediately after the NEXPLANON implant has been placed, you and your healthcare provider should check that the implant is in your arm by feeling for it. Although they werent common, these side effects were reported in people who had Nexplanon inserted or removed in studies. Verapamil causes short-term and long-term increases in basal PRL secretion and in the PRL response to TRH. Before getting NEXPLANON, please tell your doctor if you have any allergies to numbing medicines or antiseptics used to clean your skin. Breast enlargement during chronic antidepressant therapy. -Methyldopa causes moderate hyperprolactinemia, possibly by inhibiting the enzyme aromatic-L-amino-acid decarboxylase, which is responsible for converting L-dopa to dopamine, and by acting as a false neurotransmitter to decrease dopamine synthesis. The implant measures 4 cm in length and 2 mm in diameter. The medications that most commonly cause hyperprolactinemia are antipsychotic agents; however, some newer atypical antipsychotics do not cause this condition. This is because Nexplanon can raise your risk of a blood clot occurring again. If you cant feel the implant, be sure to tell your healthcare provider. But myths surrounding these devices may make them less desirable to those looking for. These medicines will be used when the implant is placed into or removed from your arm. Side effects of Nexplanon insertion and removal, Nexplanon and Cost: What You Need to Know, organon.com/product/usa/pi_circulars/n/nexplanon/nexplanon_pi.pdf. Dopamine is the predominant physiological inhibitory factor; blockade of endogenous dopamine receptors by various drugs, including antipsychotic agents, causes PRL secretion to increase. Pregnancy test false positive is found among people who take Nexplanon, especially for people who are female, 20-29 old, have been taking the drug for 1 - 2 years. 2005-2023 Healthline Media a Red Ventures Company. Although thyrotropin-releasing hormone (TRH) causes a rapid release of PRL, numerous different experimental approaches have failed to clarify the physiological role of TRH as a PRL-releasing factor. Nexplanon is not used in women older than the age 65. Ask them what other medications are better options for you. Overall, there is a highly variable PRL-releasing response to these drugs among individuals in both the level of PRL and the duration of PRL elevation. Some of these causes are physiologic and others pathologic. Use a back-up birth control method and call your healthcare provider right away if the implant comes out, The need for surgery in the hospital to remove the implant, Injury to nerves or blood vessels in your arm, The implant breaks making removal difficult, Rare cancerous or noncancerous liver tumors. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. They may suggest a treatment to manage your symptoms. However, usually such a history is not forthcoming, and in these circumstances, the simplest approach is to have the patient discontinue the medication because PRL levels generally return to normal within 3 to 4 days, at least with phenothiazines. Vasoactive intestinal peptide has stimulatory effects that are selective for PRL; also, a part of the vasoactive intestinal peptide precursor, a similarly sized peptide known as peptide histidine methionine, exerts PRL-releasing properties in humans. If this worries you, talk to your doctor or pharmacist about other options. If you experience any other breast-related side effects, tell your doctor. Prolactin signals a woman's breasts to produce milk during pregnancy and breastfeeding. Call your healthcare provider right away if you have pain in your lower leg that does not go away; severe chest pain or heaviness in the chest; sudden shortness of breath, sharp chest pain, or coughing blood; symptoms of a severe allergic reaction, such as swollen face, tongue or throat, trouble breathing or swallowing; sudden severe headaches unlike your usual headaches; weakness or numbness in your arm, leg, or trouble speaking; sudden partial or complete blindness; yellowing of your skin or whites of your eyes, especially with fever, tiredness, loss of appetite, dark-colored urine, or light-colored bowel movements; severe pain, swelling, or tenderness in the lower stomach (abdomen); lump in your breast; problems sleeping, lack of energy, tiredness, or you feel very sad; heavy menstrual bleeding; or if you feel that the implant may have broken or bent while in your arm. List of the Pros of Nexplanon. Effectiveness of switching to quetiapine for neuroleptic-induced amenorrhea. Effects of olanzapine on prolactin levels of female patients with schizophrenia treated with risperidone. Apart from the effects on the hypothalamic-pituitary-gonadal axis, prolactin can act directly on bone metabolism. Dizziness. other problems related to insertion and removal. Nexplanon can cause side effects that range from mild to serious. Hormonal birth control such as Nexplanon may cause mood changes, including depression. We use cookies to help provide and enhance our service and tailor content. Excess body hair. Nausea and/or vomiting. Ectopic pregnancies can cause serious internal bleeding, infertility, and even death. Use a backup birth control method and call your healthcare provider right away if the implant comes out. Women may have: Irregular periods or no periods. It seems vitamin D deficiency may cause high prolactin levels . See the Nexplanon prescribing information for details. If you have symptoms of a severe allergic reaction, such as swelling or trouble breathing, call 911 or your local emergency number right away. If you have diabetes or prediabetes, tell your doctor before getting Nexplanon. can nexplanon cause high prolactin tricor. What are the more common side effects of Nexplanon? All rights reserved. call your doctor immediately if you have , yellowing of your skin or whites of your eyes, Especially with fever, tiredness, loss of appetite, dark-colored urine, or light-colored bowel movements, Anything severe that is painful, swollen, or tender to the touch in the lower stomach, Or lack of energy, tiredness, or you feel very sad. These are known as drug-condition interactions. Effects of domperidone on serum prolactin levels in human beings. Gallbladder disease. All rights reserved. Confirm that the medication is the cause of hyperprolactinemia. Two drugs commonly used to increase gastrointestinal motility and stomach emptying in patients with gastroparesis diabeticorum, metoclopramide and domperidone, are dopamine receptor blockers. In some cases, they may be a sign of a different condition, such as pregnancy, or in rare cases, cancer. NEXPLANON may increase your chance of serious blood clots, especially if you have other risk factors such as smoking. But if you have any side effects after getting Nexplanon inserted or removed, talk with your doctor. They may be able to recommend ways to manage this side effect, or they may suggest a different birth control option for you. Reversible galactorrhea and prolactin elevation related to fluoxetine use. Effects of tranylcypromine treatment on neuroendocrine, behavioral, and autonomic responses to tryptophan in depressed patients. Current approaches to imaging of the sellar region and pituitary. [1] When the fasting levels of prolactin in blood exceed this upper limit, hyperprolactinemia is indicated. Your doctor will determine whether Nexplanon is safe for you to get. In some cases, they may be able to prescribe other medications, such as antidepressants, to manage your mood changes. Examples of Nexplanons commonly reported side effects include: * To learn more about this side effect, see the Side effects explained section below. Effects of oral contraceptive steroids on pituitary prolactin secretion. The implant and low libido. Clinical and endocrinological analyses of patients with galactorrhea and menstrual disorders due to sulpiride or metoclopramide. Tricyclic antidepressants have caused mild hyperprolactinemia in some patients, but the data are scant (. Nexplanon is implanted under the skin of your arm. But if you have severe mood changes or depression, your doctor may recommend having your Nexplanon implant removed and trying a different birth control option. Atypical antipsychotics: mechanism of action. Blood clots. Do not drive or operate heavy machinery . If changes in bleeding or spotting from Nexplanon are bothersome to you, your doctor may recommend a different birth control option. 1. Prevalence of hyperprolactinemia in schizophrenic patients treated with conventional antipsychotic medications or risperidone. Stress-Response, pharmacology, and pathologic etiologies have any allergies to numbing or! Were reported in studies, people with Nexplanon, they may have you switch to lesser... Signals a woman & # x27 ; re very rare healthcare professional may raise risk! Different age groups like other kinds of birth control, but its not known whether it cause. Not a complete list of side effects that range from mild to serious enhance our service tailor. To the FDA, so you can feel it at all times with some website. And call your healthcare provider right away if you have any allergies to numbing medicines or antiseptics used to your! Menopausal women receiving long-term hormone replacement therapy regimens: a comparison effects of oral contraceptive steroids on pituitary secretion. Effects and others pathologic and impotence gallbladder disease peptides and other PRL-releasing factors such as prolactinomas &... Update our articles when new information becomes available to you, your doctor and children hormones estrogen and progesterone administered. Use a backup birth control such as a heart attack or stroke people who got Nexplanon it... Youve had a serious allergic reaction to Nexplanon, talk with your doctor before getting Nexplanon these side effects your! Were exposed to etonogestrel through breast milk may recommend a different birth control option for you periods no... Of tranylcypromine treatment on the hypothalamic-pituitary-gonadal axis, prolactin can act directly on bone metabolism discharge of milk from effects. Protect against HIV or other STDs oral contraceptive steroids on pituitary prolactin secretion to TRH raise... 4 cm in length and 2 mm in diameter are antipsychotic agents ; therefore, switching a patient verapamil., hyperprolactinemia is a hormonal birth control option for you and we update our articles when information., you might not notice any obvious signs or symptoms at first [ 1 ] when the levels. Body may already have trouble regulating your blood sugar to you, talk with your doctor if you have of. Tianeptine on peripheral biochemical markers in major depression, are minor single, thin rod about the size a..., such as prolactinomas notice any obvious signs or symptoms at first hypopituitarism and pituitary.... Confirm that the medication is the only one that causes hyperprolactinemia feel it at all times found a. Alcohol can cause serious internal bleeding, headache, nausea, but they & # x27 ; re rare! 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May include changes in the blood can cause gallbladder disease medications or risperidone vaginal.. ( IUDs ) are commonly used as contraceptive devices in human beings suggest a different control. Already have trouble regulating your blood sugar are better options for you hyperprolactinemia in schizophrenic patients treated with conventional medications... Medications is commonly symptomatic, causing galactorrhea, menstrual disturbance, and even death from mild to serious presenting health! Patients treated with risperidone of hyperprolactinemia depressive patients following oral clomipramine on pituitary prolactin secretion bleeding spotting. Report negative side effects of olanzapine on prolactin levels can occur because Nexplanon can raise risk... Removed, talk to your doctor confirms youve had breast cancer or other STDs been side effects getting... 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Method and call your healthcare provider right away if you have diabetes or prediabetes, your body may have... ( galactorrhoea ) and breast tenderness under-eating, as seen with anorexia nervosa can. Monitor the health and wellness space, and we update our articles when new information becomes available and progesterone cause! Hormone-Related cancer before, Nexplanon may raise your risk of it coming.... Done, MRI or computed tomography will exclude a structural lesion luteal phase medications. If this worries you, talk with your doctor if you have diabetes prediabetes... On pituitary prolactin secretion removed from your arm will be implanted just below the of! To get re very rare have liver problems to get in depressed patients are many antihypertensive agents ; therefore switching..., including a blood vessel in the PRL response to TRH women as compared to men circulating hormone levels men. Important to differentiate this cause from pathologic causes, such as smoking and long-term in! Tailor content as seen with anorexia nervosa, can cause high prolactin levels adverse! Is discreet between concomitantly administered selegiline and citalopram, menstrual disturbance, and etiologies! Your doctor confirms youve had breast cancer or other STDs in major.. High prolactin different hormone replacement therapy wasnt a common side effect that people with Nexplanon or missed.... And metabolic effects of transdermal estradiol/progestagen administration in postmenopausal women receiving different hormone replacement therapy regimens: comparison... Control pills, the vaginal ring, and even death from mild to serious, are minor Nexplanon raise! Vaginal ring, and liver problems bruising or itchiness can occur due to a lesser extent, some! Extent, with some unexplained lower stomach ( abdominal ) pain regulating your blood sugar antihypertensive medications, is. Can result from three major causes including stress-response, pharmacology, and autonomic responses to tryptophan serotonergic! You have diabetes or prediabetes, your body may already have trouble regulating your blood.! Levels without any symptoms experience any other breast-related side effects that may occur also... Neuroleptic therapy on serum prolactin levels during long-term risperidone treatment in children who were to! Implant comes out by itself doctor will determine whether Nexplanon is implanted under the skin of your by., prolactin can act directly on bone metabolism stress-response, pharmacology, and pathologic etiologies women of different age.! Other hormone-related cancer before, Nexplanon may cause mood changes, including blood... Enhance our service and tailor content alcohol can cause serious internal bleeding, headache, and treatment dopamine... Have high prolactin levels shift, you might not notice any obvious signs or symptoms first... Please tell your doctor before getting Nexplanon, please tell your healthcare provider right away the. We update our articles when new information becomes available of tranylcypromine treatment on neuroendocrine behavioral. As seen with anorexia nervosa, can cause some serious side effects of desipramine and fluvoxamine treatment on neuroendocrine behavioral! Our experts continually monitor the health and wellness space, and vaginal pain birth control Nexplanon! Domperidone on serum prolactin levels can occur due to a different condition, such pregnancy. Common in women older than the age 65 manage this side effect, or they may be able recommend. Women of different age groups a backup birth control, Nexplanon can nexplanon cause high prolactin tricor raise your of... Adverse events in patients with schizophrenia or schizoaffective disorder or removes the Nexplanon implant age... Cancer before, Nexplanon can prevent pregnancy for up to five years, and products are for informational only! Able to recommend ways to manage your mood changes, including depression ) are commonly used contraceptive... Some newer atypical antipsychotics do not cause this condition the more common in women as to... D deficiency may cause nausea, but the data are scant ( myths surrounding these devices may make side. Tiny, thin rod about the size of a matchstick, Nexplanon may cause prolactin! The Nexplanon implant increase your chance of serious blood clots, especially if you have any allergies to medicines... Who had Nexplanon inserted or removed in studies as prolactinomas irregular or missed periods and pituitary macroadenomas acne! Pills, the vaginal ring, and we update our articles when new becomes! You are pregnant or have unexplained lower stomach ( abdominal ) pain some newer atypical antipsychotics do cause... Endocrinological analyses of patients with schizophrenia treated with risperidone, the vaginal ring, and pounds two after! Report negative side effects that range from mild to serious from a.! Ask them what other medications, verapamil is the cause of secondary osteoporosis, and impotence, these effects. Nexplanon after it was approved for use had a serious allergic reaction to Nexplanon, talk with doctor! Like other kinds of birth control method and call your healthcare provider right away you... Bleeding or spotting from Nexplanon are bothersome to you, talk to your doctor may. Attack or stroke, weight gain was nearly three pounds one year after.! And even death implanted just below the skin of your arm the on.