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Brenner succeeds Kristiina Vuori, M.D., Ph.D., who announced her intention to step down as president in January after serving in the role for the past 12 years. Nelson K, Foufoula-Georgiou E, Gelfand M. The role of Mesothelin signaling in Portal Fibroblasts in the pathogenesis of cholestatic liver fibrosis. 2007 Dec; 47(6):834-43. Loomba R, Seguritan V, Li W, Long T, Klitgord N, Bhatt A, Dulai PS, Caussy C. YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity. Harada N, Hatano E, Koizumi N, Nitta T, Yoshida M, Yamamoto N. c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation. Transient induction of c-jun during hepatic regeneration. TNF alpha-induced hepatocyte apoptosis is associated with alterations of the cell cycle and decreased stem loop binding protein. Nature. Proc Natl Acad Sci U S A. Expression of small heat shock protein alphaB-crystallin is induced after hepatic stellate cell activation. DNA Cell Biol. Hepatobiliary Surg Nutr. J Gastroenterol. 2010 Oct; 52(4):1420-30. Caussy C, Tripathi A, Humphrey G, Bassirian S, Singh S, Faulkner C, Bettencourt R. Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice. 2019 11 05; 30(5):850-852. J Biol Chem. Aliment Pharmacol Ther. 2021 11; 25(11):2149-2159. Biotechniques. Hepatology. 2002 Aug 15; 100(4):1470-7. Mechanisms of fibrogenesis. MELD and the practicing gastroenterologist. J Bone Miner Res. Clin Gastroenterol Hepatol. 2008 Aug; 42(5):349-61. Hum Mol Genet. 1996 Sep; 24(3):670-6. 1994 Sep; 3(9):1695-7. 2019 01; 49(2):183-193. Fibrogenesis of parenchymal organs. Gbele E, Reif S, Tsukada S, Bataller R, Yata Y, Morris T, Schrum LW. Hepatol Commun. J Clin Exp Hepatol. Hepatology. 1990; 14(6):639-45. Liver Int. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. 2010 Feb 25; 3:39-47. J Hepatol. Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. J Clin Gastroenterol. Neurology. Gut. Mol Cell Biol. WebBrenners wife, Jill Silverman Brenner, M.D., is a primary care internist and rheumatologist. Cell Metab. 2016 Sep; 92(3):84-92. Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. Koch KS, Fletcher RG, Grond MP, Inyang AI, Lu XP. The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. 2014 Aug; 124(8):3566-78. Surgery. Hepatology. Nat Clin Pract Gastroenterol Hepatol. Caussy C, Bhargava M, Villesen IF, Gudmann NS, Leeming DJ, Karsdal MA, Faulkner C, Bao D, Liu A, Lo MT, Bettencourt R, Bassirian S. The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma. Yan AW, Fouts DE, Brandl J, St?rkel P, Torralba M, Schott E. Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. Gastroenterology. Cell Death Differ. Interactions between the intestinal microbiome and liver diseases. Hepatology. Report of the American Gastroenterological Association (AGA) Institute Obesity Task Force. 2008 Jun; 118(6):2121-31. Am J Physiol. J Theor Biol. Clin Res Hepatol Gastroenterol. 2013 Jun; 45(6):450-9. 1999 Jun; 29(6):1680-9. Schnabl B, Hu K, Mhlbauer M, Hellerbrand C, Stefanovic B. Clin Gastroenterol Hepatol. 2003 May; 37(5):1043-55. 1995 Sep 29; 270(39):22689-92. Luedde T, Assmus U, Wstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K. Information assimilation and distribution challenges and goals for real and virtual journals. Clin Gastroenterol Hepatol. Sols-Herruzo JA, Rippe RA, Schrum LW, de La Torre P, Garca I, Jeffrey JJ, Muoz-Yage T. NF-kappaB inhibits expression of the alpha1(I) collagen gene. Paik YH, Kim J, Aoyama T, De Minicis S, Bataller R. Transcriptional repression of the transforming growth factor (TGF-) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor ?B (NF-?B) p50 enhances TGF- signaling in hepatic stellate cells. Integr Biol (Camb). 2010 Jul-Aug; 19(4):311-20. Cell Death Differ. The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. Adler DH, Cogan JD, Phillips JA, Schnetz-Boutaud N, Milne GL, Iverson T, Stein JA. Hepatology. The renin-angiotensin-aldosterone system in cerebral small vessel disease. Lehmann TG, Wheeler MD, Schwabe RF, Connor HD, Schoonhoven R, Bunzendahl H. Tumor necrosis factor alpha prevents tumor necrosis factor receptor-mediated mouse hepatocyte apoptosis, but not fas-mediated apoptosis: role of nuclear factor-kappaB. The fecal microbiome of ALS patients. 2000 Jan; 48(1):39-44. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. 1998 Oct; 27(3):192-8. J Biol Chem. Gastroenterology. Targeted disruption of the mouse ferrochelatase gene producing an exon 10 deletion. 2016 Feb; 43(2):179-87. Nature. 1999 Aug; 21(2):238-45. 1984; 49:151-60. Rhoads JM, Argenzio RA, Chen W, Graves LM, Licato LL, Blikslager AT, Smith J, Gatzy J. Nat Med. Gastroenterology. 2006 May; 130(6):1564-72. 2016 08; 44(3):287-99. GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis. Lab Invest. 2005 Sep; 230(8):573-86. Proc Natl Acad Sci U S A. Am J Physiol Gastrointest Liver Physiol. Hepatology. Serum levels of alanine aminotransferase decrease with age in longitudinal analysis. 2011 Apr; 300(4):G516-25. Am J Physiol. 2011 Jan; 53(1):96-105. 2017 Jun 30; 127(7):2697-2704. Immunotherapy-based targeting of MSLN+ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis. Lopez-Sanchez I, Dunkel Y, Roh YS, Mittal Y, De Minicis S, Muranyi A, Singh S, Shanmugam K, Aroonsakool N, Murray F. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. Microbiome 101: Studying, Analyzing, and Interpreting Gut Microbiome Data for Clinicians. Norepinephrine induces calcium spikes and proinflammatory actions in human hepatic stellate cells. Mol Genet Genomic Med. Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium. Transforming growth factor-beta 1: there is regulation beyond transcription. 2021 03; 18(3):151-166. 1993 Sep; 92(3):1336-48. Hepatology. Adenovirus-Mediated expression of a nuclear factor kappaB super-repressor in human hepatic stellate cells 1993 15. 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